Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients

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Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients.

Chronic infection perturbs immune homeostasis. While prior studies have reported dysregulation of effector and memory cells, little is known about the effects on naïve T cell populations. We performed a cross-sectional study of chronic hepatitis C (cHCV) patients using tetramer-associated magnetic enrichment to study antigen-specific inexperienced CD8(+) T cells (i.e., tumor or unrelated virus-...

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ژورنال

عنوان ژورنال: eLife

سال: 2015

ISSN: 2050-084X

DOI: 10.7554/elife.07916